The Technology

Most medicines are not available in liquid form because the majority of drugs are insoluble, or only sparingly soluble, in water or any other acceptable solvent.

To be administered as a liquid, an insoluble  drug must be suspended. However suspended medicines undergo sedimentation on standing, leading to a risk of under or overdosing. Also, only relatively low concentrations of insoluble drug can be suspended, without the liquid becoming unacceptably viscous.

For these reasons the use of oral suspensions have largely been confined to paediatric medicine, where only a fraction of the adult dose may be required.

Attempts to solve the problem of dispersing pharmaceuticals in water have usually involved the use of thickeners (e.g. gums or polymers) to raise the viscosity of the liquid medium, or viscosifiers to make colloidal dispersions. However, such systems are difficult to handle and are often incapable of dispersing relatively coarse particles.

BioSuspensions has developed a new and novel Structured Suspension System for oral and parenteral applications, which relies on the rheological properties of the suspending medium to immobilise particles, irrespective of size.

The result is a uniquely robust, low viscosity system with excellent suspension properties, tasteless constituents, and able to tolerate the presence of high levels of sugar, if desired, e.g. in oral preparations to mask any unpleasant taste of the suspended drug.

To find out more about our patented structured suspension systems, please contact us at enquiry@biosuspensions.com